Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State
نویسندگان
چکیده
منابع مشابه
Monounsaturated Fatty Acids in Birds
23 The evolution of lifespan is a central question in evolutionary biology, begging the question why 24 there is so large variation among taxa. Specifically, a central quest is to unravel proximate causes of 25 ageing. Here we show that the degree of unsaturation of liver fatty acids predicts maximum lifespan 26 in 107 bird species. In these birds, the degree of fatty acid unsaturation is posit...
متن کاملPeroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.
Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid peroxidase, cause lethal accumulation of lipid peroxides and induce ferroptotic cell death. Although ferroptosis has been suggested to involve accumulation of reactive oxygen species (ROS) in lipid environments, the m...
متن کاملIdentification of some uncommon monounsaturated fatty acids of bacteria.
Location of the double-bond position of monounsaturated fatty acids of various bacteria was accomplished with combined gas chromatography-mass spectrometry analysis of dimethyl disulfide (DMDS) derivatives. The monoenoic fatty acids from whole cells were converted to methyl esters and then to DMDS adducts and analyzed by capillary gas chromatography-mass spectrometry. The mass spectra of DMDS a...
متن کاملAvocados (monounsaturated fatty acids), weight loss and serum lipids
The consumption of diets enriched with monounsaturated fatty acids have been related to a lower rate of coronary heart disease, mainly due to their positive effects on serum lipids. The avocado is a fruit rich in monounsaturated fatty acids and other nutrients, offering protection against coronary heart disease. This article will review the scientific evidence on avocados, and their impact on w...
متن کاملKinetics of Saturated, Monounsaturated, and Polyunsaturated Fatty Acids in Humans
Plasma free fatty acid (FFA) kinetics in humans are often measured with only one tracer. In study 1, healthy volunteers received infusions of [U-¹³C]linoleate, [U-¹³C]oleate, and [U-¹³C]palmitate during continuous feeding with liquid meals low (n = 12) and high (n = 5) in palmitate and containing three labeled fatty acids to measure FFA appearance and fractional spillover of lipoprotein lipase-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Chemical Biology
سال: 2019
ISSN: 2451-9456
DOI: 10.1016/j.chembiol.2018.11.016